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What Is Psilohuasca? How and Why This Psychedelic Combo Is Going Mainstream

Evan Lewis-Healey
5 min readMay 18, 2021

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What is psilohuasca and how is it changing psychedelic healing? Everything you need to know.

Photo by FLY:D on Unsplash

As psychedelics are merging into the mainstream, interest is flocking to other types of plant medicine. While many people are aware of the benefits of psychedelics such as psilocybin, and empathogens such as MDMA, there are still many unknowns in the psychedelic world. One psychedelic that you may not have heard of is psilohuasca.

What is Ayahuasca?

To find out what psilohuasca is, we first need to know what comprises ayahuasca. Ayahuasca is a psychedelic brew primarily used in the Amazonian basin. The brew contains the psychoactive component dimethyltryptamine (DMT), one of the most potent psychedelic substances known to humankind.

Traditionally, the plants that make up this brew are Banisteriopsis caapi, an Amazonian vine containing monoamine oxidase inhibitor (MAO-inhibitor), and Psychotria viridis, also known as chacruna (which contains DMT).

It is the combination of these two plants that allows the DMT to have an effect on the brain. On its own, DMT can be processed and smoked, leading to a short-lived and intense psychedelic journey. However, if taken orally, DMT is broken down very quickly in the body by…

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Evan Lewis-Healey
Evan Lewis-Healey

Written by Evan Lewis-Healey

PhD candidate at Cambridge University. Studying the cognitive neuroscience of altered states of consciousness.

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