Forgotten Psychedelics: What Is 2C-B?

Synthesised by Alexander Shulgin, famous chemist and psychonaut, this substance has a unique profile of psychedelic-like effects.

Evan Lewis-Healey
4 min readNov 9, 2021
Retrived from Max Pixel

When you think of psychedelics, substances such as LSD, psilocybin, or perhaps even MDMA, immediately come to mind. The 1970s, however, was a golden age of discovery in the pharmacological world of psychedelics, leading to 2C-B.

The substance is unique: it’s understudied, its effects are unlike other psychedelics, and it’s often unheard of. Here we’ll explore the history, the effects, and the potential therapeutic application, of this unique psychedelic.

Tripping Through Time: The History of 2C-B

4-Bromo-2,5-dimethoxyphenethylamine (also known as Nexus, Erox, or 2C-B) was synthesized by a famous American pharmacologist and psychonaut, Alexander Shulgin, in 1974.

In his lifetime, Shulgin was responsible for the synthesis and discovery of over 230 novel psychoactive compounds. More than that, he was a devout psychonaut, exploring the realms of his consciousness with all of his pharmacological creations (he allegedly tripped some 10,000 times). However, 2C-B was up there as one of Shulgin’s most preferred psychedelic journeys.

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Evan Lewis-Healey

PhD candidate at Cambridge University. Studying the cognitive neuroscience of altered states of consciousness.